Another type of frameshifting may also occur in bacterial insertion
sequences. This occurs at the transcriptional level and involves misreading and
slippage of RNA polymerase on stretches of A residues. Although no real data is
at present available, it may occur relatively frequently (Baranov, et al.,
2005, Baranov, et al., 2006, Sharma, et al., 2011)
PV, Fayet O, Hendrix RW & Atkins JF (2006) Recoding in bacteriophages and
bacterial IS elements. Trends Genet 22: 174-181.
PV, Hammer AW, Zhou J, Gesteland RF & Atkins JF (2005) Transcriptional
slippage in bacteria: distribution in sequenced genomes and utilization in IS
element gene expression. Genome Biol 6: R25.
- Sharma V, Firth AE, Antonov I, Fayet
O, Atkins JF, Borodovsky M & Baranov PV (2011) A pilot study of bacterial
genes with disrupted ORFs reveals a surprising profusion of protein sequence
recoding mediated by ribosomal frameshifting and transcriptional realignment. Mol Biol Evol 28: 3195-3211.