Programmed transcriptional
frameshifting
Another type of frameshifting may also occur in bacterial insertion
sequences. This occurs at the transcriptional level and involves misreading and
slippage of RNA polymerase on stretches of A residues. Although no real data is
at present available, it may occur relatively frequently (Baranov, et al.,
2005, Baranov, et al., 2006, Sharma, et al., 2011)
References :
- Baranov
PV, Fayet O, Hendrix RW & Atkins JF (2006) Recoding in bacteriophages and
bacterial IS elements. Trends Genet 22: 174-181.
- Baranov
PV, Hammer AW, Zhou J, Gesteland RF & Atkins JF (2005) Transcriptional
slippage in bacteria: distribution in sequenced genomes and utilization in IS
element gene expression. Genome Biol 6: R25.
- Sharma V, Firth AE, Antonov I, Fayet
O, Atkins JF, Borodovsky M & Baranov PV (2011) A pilot study of bacterial
genes with disrupted ORFs reveals a surprising profusion of protein sequence
recoding mediated by ribosomal frameshifting and transcriptional realignment. Mol Biol Evol 28: 3195-3211.